HydroxytyroWHAT?????????


Hi! And Welcome back! Can you believe that when I started typing this morning I couldn’t find the question mark key on my keyboard? In my fifteen or so years of using a keyboard to convey my thoughts, I don’t think it’s ever moved — except for that fall I spent studying in England. Talk about a typing wake-up call! Thankfully, as evidenced by the title of this blog, I found it.

Hydroxytyrosol.

Lets break it down:

Hydroxy – A prefix. Shows the presence of a hydroxyl functional group (-OH)
*Hydroxyl – a compound containing an oxygen atom bound covalently with a hydrogen atom.

Tyrosol – A natural phenolic antioxidant present in a variety of natural sources. The principal source in the human diet is olive oil.

Hydroxytyrosol – A phytochemical with antioxidant properties. Found on the exterior of the green olive fruit, it is believed to be one of the most powerful antioxidants.

Hydroxytyrosol Structure

So, your asking yourself: What does this have to do with me?

Well, if you’ll recall. Yesterday, I promised to share with you a variety of things about my journey in discovering what it means to “Honor who you are everyday.” As part of that, I promised to keep you up-to-date on the latest scientific news and research findings that are really important to us here at Pinnnaclife. And here’s why:

Hydroxytyrosol is a compound contained in Olivamine10 AND in Olivamine.

Olivamine® and Olivamine10 are the inventions of world-reknowned Biochemist (and my boss), Dr. Darlene McCord.

Olivamine10 is the main component of Pinnaclife supplements.

Olivamine® which is the key ingredient in her “Remedy” skin and wound care line. Which is currently the number 1 selling line in the North America. Why? Because it works. That’s another story. So,

At the risk of sounding scientific:

Hydroxytyrosol is a tiny fraction of the green olive found on the fruit’s outer membrane. It is the second most potent antioxidant known today, second only to gallic acid in oxygen radical absorbance capacity (ORAC) values. It has been shown to pass into the cell’s nuclear envelope and activate the MnSOD gene. This activation has proven to enhance MnSOD activity 5-fold. MnSOD is required to protect the mitochondria from free radical damage thus protecting the cell from premature death. Hydroxytyrosol also passes the blood brain barrier where it also serves as a metabolite of the neurotransmitter dopamine.

In terms for everyone:

Hydroxytyrosol has incredible anti-aging properties. It has been shown to aid in a decreased risk of cardiovascular disease by preventing low-density lipoprotein oxidation. It is very useful in the treatment of oxidative stress associated with neurodegenerative disease. It is believed to be the highest free radical scavenging antioxidant. It is necessary to fight damage caused by free radicals.

“So what’s the big news?” You ask, “Why, Kevin? Why is this so important?”

Scientists from the University of Iowa submitted an article detailing the findings of their study on October 27th, 2010. The article was reviewed and accepted on February 15th, 2011, and was JUST published in AGE Magazine earlier this week. AGE is the peer reviewed journal for the American Aging Association, a top 5 scientific publication on age related sciences.
This article is titled MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan (Heads up, this is the link to the COMPLETE Article. It’s a big file so it will probably take a minute to download)

And what does that mean?

Here again with the Science is the Abstract from the study:

Chronological lifespan (CLS) is defined as the duration of quiescence in which normal cells retain the capacity to reenter the proliferative cycle. This study investigates whether hydroxytyrosol (HT), a naturally occurring polyphenol found in olives, extends CLS in normal human fibroblasts (NHFs). Quiescent NHFs cultured for a long duration (30–60 days) lose their capacity to repopulate. Approximately 60% of these cells exit the cell cycle permanently; a significant increase in the doubling time of the cell population was observed. CLS was extended in quiescent NHFs that were cultured in the presence of HT for 30–60 days. HT-induced extension of CLS was associated with an approximately 3-fold increase in manganese superoxide dismutase (MnSOD) activity while there was no change in copper–zinc superoxide dismutase, catalase, or glutathione peroxidase protein levels. Quiescent NHFs overexpressing a dominant-negative mutant form of MnSOD failed to extend CLS. HT suppressed age-associated increase in mitochondrial ROS levels. Results from spectroscopy assays indicate that HT in the presence of peroxidases can undergo catechol–semiquinone–quinone redox cycling generating superoxide, which in a cellular context can activate the antioxidant system, e.g., MnSOD expression. These results demonstrate that HT extends CLS by increasing MnSOD activity and decreasing age-associated mitochondrial reactive oxygen species accumulation.

And in terms for everyone:

The specific dosing of hydroxytyrosol, a key ingredient in Olivamine10 and in Olivamine®, has been scientifically proven to extend the chronological life of normal human fibroblasts by 20% in a disease free state.

This is huge. Science is important and when it backs our products and compounds, it adds important credit where credit is due. It supports our work and brings us leaps and bounds closer to realizing our goals.

Thank you for your time today. As we move forward, I want you all to be informed. Believe it or not, an important part of any wellness plan is education. The more we know about what we are putting into our bodies, the better chance we have at staying heathy and being well. Thanks again

Kevin

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